Carbocysteine is S-(carboxymethyl) cysteine. Molecular Formula: HOOC-CH2-S-CH2-CH(NH2)-COOH.
Mucolytic agent for oral administration.
Pharmacology: Flemex acts on the mucosa of the airway by altering the synthesis of respiratory mucus which is produced by irritated mucosa and liquefying the mucus for easy expectoration.
Loosens mucus and eases cough.
Respiratory disorders characterized by excessive or viscous and tenacious mucus eg, cold, acute and chronic bronchitis, bronchiectasis, tracheobronchitis, asthmatic bronchitis and emphysema.
Flemex: In otorhinolaryngology, Flemex is indicated as adjunctive therapy in otitis, sinusitis, nasopharyngitis, tubal otorrhea and in reducing hypersecretion prior to surgery.
Tablet: Adults: 2 tabs 3 times daily. This can be reduced to 1 tab 3 times daily after a satisfactory response has been obtained.
Syrup: 250 mg/5 mL: Adults: 1 tbsp 3 times daily. Children 5-12 years: 1 tsp 3 times daily; 2-5 years: 1 tsp 1-2 times daily or as prescribed by physician. 100 mg/5 mL: Children 2-5 years: 1 teaspoonful (5 mL) 1-2 times daily. Infants and children <2 years: ½ teaspoonful (2.5 mL) 1-2 times daily.
Cases of overdosage with carbocysteine have not been reported. In case of overdosage, the patient should have nausea and vomiting. If vomiting does not occur, it can be induced by conventional means, including gastric lavage.
Hypersensitivity to carbocysteine or the presence of an active peptic ulcer. Although there is no evidence that carbocysteine has any physical or chemical effect on gastric mucus, the possibility of a change in gastric mucus cannot be excluded.
Patients with a history of peptic ulcer should be examined to exclude the presence of an active ulcer before administering Flemex/Flemex Kids.
Flemex: Use of antitussive agents concomitantly with Flemex is not recommended.
Be cautious in use of Flemex due to 5% alcohol content.
Flemex Kids: During the treatment, patients should be reminded to expect an increase in the flow of secretion.
Use in pregnancy: Although animal testing demonstrated no teratogenic effect, the safe use of Flemex/Flemex Kids in pregnancy has not been established.
Use in pregnancy: Although animal testing demonstrated no teratogenic effect, the safe use of Flemex/Flemex Kids in pregnancy has not been established.
Adverse incidence is approximately 3.5%. Most common are mild gastrointestinal symptoms and nausea, which subside with lowering of dosage or discontinuance of treatment.
In human studies, no interference was noted with the activities of antibiotics, sulfonamides, antihistamines or corticosteroids. In animal studies, no interference was noted with the activities of epinephrine, amphetamines, barbiturates or reserpine.
R05CB03 - carbocisteine ; Belongs to the class of mucolytics. Used in the treatment of wet cough.
Flemex: Chewable tab 375 mg (orange flavour) x 50 x 10's. Syr 250 mg/5 mL x 30 mL (raspberry & menthol flavour) x 1's, 60 mL (raspberry & menthol flavour) x 1's.
Flemex Kids: Syr 100 mg/5 mL (raspberry & strawberry flavour) x 60 mL x 1's.
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